Metabolic Syndrome News -
from March 2008
Epidemiology

Poststroke mortality inversely related to
body mass index
(Posted: March 31, 2008) | View

Television-viewing time positively associated with a number of metabolic risk variables
(Posted: March 25, 2008) | View

Alanine aminotransferase associated with an adverse atherothrombotic and metabolic risk profile in a British South Asian population
(Posted: March 21, 2008) | View

Several components of the metabolic syndrome associated with cardiovascular disease in elderly Italians
(Posted: March 20, 2008) | View

Adiponectin associated with adverse cardiovascular outcome in patients with manifest coronary artery disease
(Posted: March 19, 2008) | View

Main lipid-related cardiovascular disease risk in Maori and Pacific people is due to their low HDL and high triglyceride levels.
(Posted: March 18, 2008) | View

Importance of sleep disordered breathing as a risk factor for clinically important levels of metabolic dysfunction
(Posted: March 17, 2008) | View

High prevalence of the metabolic syndrome as an emerging health problem in Iranian women
(Posted: March 13, 2008) | View

Strong association between obesity and C-reactive protein in African-Americans and in Hispanic-Americans
(Posted: March 11, 2008) | View

Strong genetic influences on childhood abdominal obesity
(Posted: March 10, 2008) | View

Low-carbohydrate diets rich in vegetable sources of fat and protein may modestly reduce the risk of diabetes
(Posted: March 7, 2008) | View

Metabolic syndrome as an important predisposing factor for depression
(Posted: March 3, 2008) | View


Screening & Diagnosis

No consistent glycaemic threshold for incident retinopathy across different populations
(Posted: March 27, 2008) | View

Circulating adiponectin level as a strong risk marker for metabolic syndrome, independent of measures of adiposity, insulin resistance and inflammatory markers
(Posted: March 5, 2008) | View


Pathophysiological Aspects

Proliferative diabetic retinopathy significantly associated with coronary atherosclerosis in the Veterans Affairs Diabetes Trial (VADT)
(Posted: March 26, 2008) | View

Metabolic syndrome strongly associated with lacunar infection in middle-aged subjects
(Posted: March 14, 2008) | View

The measurement of dysfunctional HDL may play an important role in coronary artery disease risk
(Posted: March 6, 2008) | View


Metabolic Syndrome Components / Risk Factors / Associated Risks

Dyslipidaemia predicts the development of hypertension in middle-aged men, independently of features related to the metabolic syndrome
(Posted: March 24, 2008) | View

Achieving low triglyceride levels may be an additional consideration beyond low LDL-cholesterol levels for patients after acute coronary syndrome
(Posted: March 12, 2008) | View


Prognosis / Outcomes
(Cardiovascular Disease)
Triglyceride/HDL-cholesterol ratio as an imperfect surrogate for insulin resistance and its associated coronary heart disease risk
(Posted: March 28, 2008) | View

Featured Upcoming Congresses
(May - August 2008)

16th European Congress on Obesity (ECO)
Date:
  May 14-17, 2008
Location:
  Geneva, Switzerland
Website:
  Click here

AACE 17th Annual Meeting and Clinical Congress
Date:
  May 14-18, 2008
Location:
  Orlando, Florida, USA
Website:
  Click here

5th World Congress on Prevention of Diabetes and its Complications
Date:
  June 1-4, 2008
Location:
  Helsinki, Finland
Website:
  Click here

3rd International Symposium on Integrated Biomarkers in Cardiovascular Disease
Date:
  July 9-11, 2008
Location:
  Seattle, WA
Website:
  Click here

Australian Diabetes Society / ADEA Annual Scientific Meeting
Date:
  August 28-30, 2008
Location:
  Melbourne, Australia
Website:
  Click here

> View all upcoming congresses

Featured Ongoing Trials

Hypoglycaemic Agents
Trial - STARR

STARR is a substudy of DREAM, with yearly carotid ultrasound examination.

Outcome:
Change of mean maximum carotid intima-media thickness (IMT) evalulated across 12 segments involving left and right common carotid, bifurcation and internal carotid arteries

Expected Total Enrollment:
1200 subjects with impaired glucose tolerance or impaired fasting glucose.

Comparisons:
Ramipril and/or rosiglitazone.

Study Design:
Randomized, double-blind, placebo control, factorial assignment.


Lipid Modifying Agents
Trial - JUPITER

Crestor 20mg Versus Placebo in Prevention of CV Events

Outcome:
Rate of major cardiovascular events.

Expected Total Enrollment:
15,000 subjects with low to normal levels LDL-cholesterol (<130 mg/dL) and elevated levels of C-reactive protein (>2.0mg/L)

Comparisons:
Resuvastatin vs placebo.

Study Design:
Randomized, double-blind, placebo control, parallel assignment.

> View all landmark studies and clinical trials




Slide Kit part 1:
The Main Threat To Human Health For The Next Decade

Slide Kit part 2:
The Double Jeopardy of the Metabolic Syndrome

Slide Kit part 3:
Defusing the Metabolic Time Bomb

Slide Kit part 4:
Combating the Metabolic Syndrome: Action Plan

Slide Kit part 5:
Metabolic Syndrome and Insulin Resistance


Framingham Risk Assessment Tool
Estimates 10-year risk of developing hard CHD
> View Tool

Procam Risk Calculator
Estimates your risk of a heart attack (myocardial infarction) within the next 10 years based upon data of the PROCAM Study
> View Calculator


SCORE
(European High Risk Chart)

Estimates 10 year risk of fatal CVD in high risk regions of Europe by gender, age, systolic blood pressure, total cholesterol and smoking status.
> View Chart

UKPDS Risk Engine
The UKPDS Risk Engine is a type 2 diabetes specific risk calculator based on 53,000 patients years of data from the UK Prospective Diabetes Study, which also provides an approximate 'margin of error' for each estimate.
> View Risk Engine


Mission of the Metabolic
Syndrome Institute

Created in 2003, the Metabolic Syndrome Institute is an independent and not for profit association. Its members are international experts in lipid metabolism, diabetes, heart disease, endocrinology obesity, genetics, epidemiology, basic research and health economics. Being the first association totally devoted to the dissemination of knowledge about the metabolic syndrome, the Metabolic Syndrome Institute will provide an international multidisciplinary approach to a worldwide public health problem.

 
Contact Metabolic Syndrome Institute
212, avenue Paul Doumer
92500 Rueil-Malmaison Cedex
FRANCE
Phone: (33) 1 41 42 20 35
Fax: (33) 1 41 42 20 01
Email:

contact@metabolic-syndrome-institute.org
Website:
http://www.metabolic- syndrome-institute.org

     
Coordinated by Dr. Scott Grundy, Past-President of the IAS