| |
This
issue highlights landmark studies
and updated guidelines
on
the metabolic syndrome in 2007.
Landmark
Studies in 2007 that Focused on Hypoglycaemic Agents
|
| Rosiglitazone
Atherosclerosis Study |
Outcome:
Change in carotid intima-media thickness.
Number of Participants:
555 subjects with type 2 diabetes mellitus or the insulin resistance syndrome;
447 completed the study.
Comparison:
Rosiglitazone
(4 mg/d for 2 months and then 8 mg/d) vs
placebo.
Design:
Randomized, double-blind, placebo-controlled.
> View
Abstract |
|
Landmark
Studies in 2007 that Focused on Lipid Modifying
Agents
|
| Investigation
of Lipid Level Management Using Coronary Ultrasound
To Assess Reduction of Atherosclerosis by CETP
Inhibition and HDL Elevation (ILLUSTRATE) Study |
Outcome:
Change in coronary artery atheroma volume as measured by intravascular ultrasound
(IVUS).
Number of Participants:
1188 with angiographic evidence of coronary atherosclerosis.
Comparison:
Torcetrapib/atorvastatis vs atorvastatin.
Design:
Randomized, double-blind, active-controlled,
parallel assignment.
> View
Abstract |
|
Measuring
Effects on Intima-Media Thickness: An Evaluation
of Rosuvastatin (METEOR) Study
|
Outcome:
Change in carotid intima-media thickness (assessed with B-mode ultrasound.)
Number of Participants:
981 asymptomatic subjects with moderately elevated cholesterol and low risk
of cardiovascular disease.
Comparison:
Rosuvastatin 40mg/d vs placebo.
Design:
Randomized, double-blind, placebo-controlled.
> View
Abstract |
|
Landmark
Studies in 2007 that Focused on Antihypertensive Agents
|
Jikei
Heart Study
|
Outcome:
Composite of cardiovascular morbidity and mortality.
Number of Participants:
3081 patients who were undergoing conventional treatment for hypertension,
coronary heart disease, heart failure, or a combination of these disorders.
Comparison:
(in addition to treatment) Valsartan
vs other treatment without angiotensin receptor
blockers.
Design:
Randomized, open label, active control,
parallel assignment.
> View
Abstract |
|
Other
Landmark Studies in 2007
|
(EVEREST)
Study
|
Outcome:
All-cause mortality and composite of cardiovascular death or hospitalization
for heart failure.
Number of Participants:
4133
patients
hospitalized
(>
48
hours
earlier)
for
exacerbation
of
chronic
heart
failure,
with
left
ventricular
ejection
fraction
<
40
signs
of
volume
expansion,
and
New
York
Heart
Association
class
III/IV
symptoms.
Comparison:
Tolvaptan vs placebo.
Design:
Randomized, double-blind, placebo-controlled.
> View
Abstract |
|
Guidelines & Recommendations
-
Updates for 2007 |
Cardiovascular
Disease |
- Evidence-based
guidelines for cardiovascular disease prevention
in women: 2007 update.
Source: American Heart
Foundation
View
Abstract
- Reducing
Risk
in
Heart
Disease
200:
Guidelines
for
preventing
cardiovascular
events
in
people
with
coronary
heart
disease.
Source: Heart Foundation
View
Abstract
|
Diabetes |
- Standards
of medical care in diabetes--2007.
Source: American
Diabetes Association
View
Abstract
|
Hypertension |
-
Canadian
Hypertension
Education
Program
(CHEP)
2007
recommendations.
Source: Canadian Hypertension
Education Program
View
Abstract
-
2007
guidelines
for
the
management
of
arterial
hypertension.
Source: European Society of Cardiology
View
Abstract
|
|
Featured Upcoming Congresses |
|
Date:
|
|
February
27 - March 1, 2008 |
Location:
|
|
Prague,
Czech Republic |
Website:
|
|
Click
here |
|
|
Date:
|
|
March
11-15, 2008 |
Location:
|
|
Colorado
Springs, CO |
Website:
|
|
Click
here |
|
| American
College of Cardiology - 57th Annual Scientific
Session |
Date:
|
|
March
29 - April 1, 2008 |
Location:
|
|
Chicago,
Illinois, USA |
Website:
|
|
Click
here |
|
| 7th
International Diabetes Western Pacific Region Congress |
Date:
|
|
March
30 - April 3, 2008 |
Location:
|
|
Wellington,
New Zealand |
Website:
|
|
Click
here |
|
| 1st
International
Congress
on
Prehypertension & Cardiometabolic
Risk |
Date:
|
|
April
2-5, 2008 |
Location:
|
|
Prague,
Czech Republic |
Email:
|
|
prehypertension@kenes.com |
|
| 16th
European Congress on Obesity (ECO) |
Date:
|
|
May
14-17, 2008 |
Location:
|
|
Geneva,
Switzerland |
Website:
|
|
Click
here |
|
| AACE
17th Annual Meeting and Clinical Congress |
Date:
|
|
May 14-18,
2008 |
Location:
|
|
Orlando,
Florida, USA |
Website:
|
|
Click
here |
|
|
|
| 
Framingham Risk Assessment Tool
Estimates 10-year risk of developing hard CHD
> View Tool
Procam Risk Calculator
Estimates your risk of a heart attack (myocardial infarction) within the next 10 years based upon data of the PROCAM Study
> View Calculator
SCORE
(European High Risk Chart)
Estimates 10 year risk of fatal CVD in high risk regions of Europe by gender, age, systolic blood pressure, total cholesterol and smoking status.
> View Chart
UKPDS Risk Engine
The UKPDS Risk Engine is a type 2 diabetes specific risk calculator based on 53,000 patients years of data from the UK Prospective Diabetes Study, which also provides an approximate 'margin of error' for each estimate.
> View Risk Engine |
| |
Mission of the Metabolic
Syndrome Institute |
Created in 2003, the Metabolic Syndrome Institute is an independent and not for profit association. Its members are international experts in lipid metabolism, diabetes, heart disease, endocrinology obesity, genetics, epidemiology, basic research and health economics. Being the first association totally devoted to the dissemination of knowledge about the metabolic syndrome, the Metabolic Syndrome Institute will provide an international multidisciplinary approach to a worldwide public health problem. |
| |
Contact Metabolic Syndrome Institute |
212, avenue Paul Doumer
92500 Rueil-Malmaison Cedex
FRANCE
Phone: (33) 1 41 42 20 35
Fax: (33) 1 41 42 20 01
Email:
contact@metabolic-syndrome-institute.org
Website:
http://www.metabolic- syndrome-institute.org |
 Metabolic
Syndrome
in the News
HIGHLIGHTS FROM JANUARY |
|
Metabolic
syndrome in childhood as predictor of adult metabolic syndrome
and type 2 diabetes 25 to 30 years later
(Posted: January 31, 2008)
Association
between depression and incident cardiovascular disease only
partly accounted
for by metabolic syndrome
(Posted: January
28, 2008)
Metabolic syndrome associated with increased
risk of chronic kidney disease in American
Indians
(Posted: January
25, 2008)
Complex relationship between excess body
weight, adiposity, and energy expenditure
among populations of African
origin
(Posted: January
24, 2008)
Metabolic
syndrome shown to vary considerably according to clinical
criteria used
(Posted:
January 22, 2008)
Indices
of abdominal obesity more predictive of coronary heart disease
than body mass
index
(Posted:
January 15, 2008)
Fitness
as a significant mortality predictor in older patients,
independent of overall
or abdominal adiposity
(Posted:
January 10, 2008)
Hypertensive patients at low-medium risk
with metabolic syndrome exhibit higher cardiovascular
risk than those without
metabolic syndrome
(Posted: January
9, 2008)
Waist-to-hip
ratio shown to be more useful than body mass index or waist
circumference
in identifying subjects
at increased risk for future cardiovascular events
(Posted: January
3, 2008)
Comparative importance of body mass index
and metabolic risk factors in predicting
10-year risk of cardiovascular
events in women
(Posted:
January 2, 2008)
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