The Metabolic Syndrome Institute Literature Watch features
the latest articles on the metabolic syndrome.
Click on the links below to view the abstracts for each article.

Adipocytes

• Regulation of adipocyte function by anthocyanins; possibility of preventing the metabolic syndrome.
  (Tsuda T.J Agric Food Chem. 2008 Feb 13;56(3):642-6. Epub 2008 Jan 23.)
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Cancer

• BRCA1 and acetyl-CoA carboxylase: the metabolic syndrome of breast cancer.
  (Brunet J, et.al. Mol Carcinog. 2008 Feb;47(2):157-63.)
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• Metabolic syndrome in sub-Saharan Africa: "smaller twin" of a region's prostatic diseases?
  (Ejike CE, et.al. Int Urol Nephrol. 2008 Feb 21; [Epub ahead of print])
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• Components of the metabolic syndrome and colorectal cancer risk; a prospective study.
  (Stocks T, et.al. Int J Obes (Lond). 2008 Feb;32(2):304-14. Epub 2007 Sep 18.)
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Cardiovascular Disease

• Metabolic syndrome and cardiovascular risk in patients with diffuse idiopathic skeletal hyperostosis.
  (Mader R, et.al. Semin Arthritis Rheum. 2008 Feb 25; [Epub ahead of print])
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• Metabolic syndrome and cardiovascular disease in the elderly: the Progetto Veneto Anziani (Pro.V.A.) Study.
  (Manzato E, et.al. Aging Clin Exp Res. 2008 Feb;20(1):47-52.)
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• Arterial stiffness in diabetes and the metabolic syndrome: a pathway to cardiovascular disease.
  (Stehouwer CD, et.al. Diabetologia. 2008 Feb 1; [Epub ahead of print])
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• The impact of metabolic syndrome on left ventricular function: Evaluated by using the index of myocardial performance.
  (Turhan H, et.al. Int J Cardiol. 2008 Feb 7; [Epub ahead of print])
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• Determining the relationship between metabolic syndrome score and angiographic severity of coronary artery disease.
  (Yavuz B, et.al. Int J Clin Pract. 2008 Feb 7; [Epub ahead of print])
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• Postprandial lipaemia, metabolic syndrome and LDL particle size in urbanised South African blacks with and without coronary artery disease.
  (Ntyintyane LM, et.al. QJM. 2008 Feb;101(2):111-9. Epub 2008 Jan 14.)
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• Prevalence of the metabolic syndrome is increased in rheumatoid arthritis and is associated with coronary atherosclerosis.
  (Chung CP, et.al. Atherosclerosis. 2008 Feb;196(2):756-63. Epub 2007 Jan 30.)
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• Metabolic syndrome and risk of development of atrial fibrillation. The Niigata Preventive Medicine Study.
  (Watanabe H, et.al. Circulation. 2008 Feb 19; [Epub ahead of print])
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Diabetes

• Waist circumference, not the metabolic syndrome, predicts glucose deterioration in type 2 diabetes.
  (Blaha MJ, et.al. Obesity (Silver Spring). 2008 Feb 14; [Epub ahead of print])
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• The metabolic syndrome as a tool for predicting future diabetes: the AusDiab study.
  (Cameron AJ, et.al. J Intern Med. 2008 Feb 20; [Epub ahead of print])
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• Metabolic syndrome and vascular alterations in normotensive subjects at risk of diabetes mellitus.
  (Ghiadoni L, et.al. Hypertension. 2008 Feb;51(2):440-5. Epub 2007 Dec 24.)
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• Renal manifestations of metabolic syndrome in type 2 diabetes.
  (Hanai K, et.al. Diabetes Res Clin Pract. 2008 Feb;79(2):318-24. Epub 2007 Nov 5.)
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• Diabetes exacerbates angiographic coronary lesion progression in subjects with metabolic syndrome independent of CRP levels.
  (Liang KW, et.al. Clin Chim Acta. 2008 Feb;388(1-2):41-5. Epub 2007 Oct 10.)
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• Prevalence of metabolic syndrome in Japanese type 2 diabetic patients and its significance for chronic vascular complications.
  (Shimajiri Y, et.al. Diabetes Res Clin Pract. 2008 Feb;79(2):310-7. Epub 2007 Oct 22.)
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• Distribution of adipose tissue: Quantification and relationship with hepatic steatosis and vascular profiles of type 2 diabetic patients with metabolic syndrome.
  (Illouz F, et.al. Diabetes Metab. 2008 Feb;34(1):68-74. Epub 2008 Feb 1.)
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Diet, Nutrition and Metabolism

• Selective loss of leptin receptors in the ventromedial hypothalamic nucleus results in increased adiposity and a metabolic syndrome.
  (Bingham NC, et.al. Endocrinology. 2008 Feb 7; [Epub ahead of print])
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• Effects of dietary fibers on disturbances clustered in the metabolic syndrome.
  (Galisteo M, et.al. J Nutr Biochem. 2008 Feb;19(2):71-84. Epub 2007 Jul 6. Review.)
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• Dietary intake and the development of the metabolic syndrome: the Atherosclerosis Risk in Communities study.
  (Lutsey PL, et.al. Circulation. 2008 Feb 12;117(6):754-61. Epub 2008 Jan 22.)
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• Renoprotective action of L-carnitine in fructose-induced metabolic syndrome.
  (Rajasekar P, et.al. Diabetes Obes Metab. 2008 Feb;10(2):171-80. Epub 2007 Dec 17.)
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• n-3 Polyunsaturated fatty acids and trans fatty acids in patients with the metabolic syndrome: a case-control study in Korea.
  (Lee E, et.al. Br J Nutr. 2008 Feb 28;:1-6 [Epub ahead of print])
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• Botanicals and the metabolic syndrome.
  (Cefalu WT, et.al. Am J Clin Nutr. 2008 Feb;87(2):481S-7S.)
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• Coffee consumption is not related to the metabolic syndrome at the age of 36 years: the Amsterdam Growth and Health Longitudinal Study.
  (Driessen MT, et.al. Eur J Clin Nutr. 2008 Feb 13; [Epub ahead of print])
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Drug Therapy

• Metabolic and clinical outcomes in nondiabetic individuals with the metabolic syndrome assigned to chlorthalidone, amlodipine, or lisinopril as initial treatment for hypertension: a report from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).
  (Black HR, et.al. Diabetes Care. 2008 Feb;31(2):353-60. Epub 2007 Nov 13.)
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• Change in metabolic syndrome parameters with antipsychotic treatment in the CATIE Schizophrenia Trial: Prospective data from phase 1.
  (Meyer JM, et.al. Schizophr Res. 2008 Feb 5; [Epub ahead of print])
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• Dose-dependent regulation of high-density lipoprotein metabolism with rosuvastatin in the metabolic syndrome.
  (Ooi EM, et.al. J Clin Endocrinol Metab. 2008 Feb;93(2):430-7. Epub 2007 Nov 20.)
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Epidemiology

• Metabolic syndrome rates in United States adolescents, from the National Health and Nutrition Examination Survey, 1999-2002.
  (Cook S, et.al. J Pediatr. 2008 Feb;152(2):165-70. Epub 2007 Oct 22.)
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• The metabolic syndrome and retinal microvascular signs in a Japanese population: the Funagata study.
  (Kawasaki R, et.al. Br J Ophthalmol. 2008 Feb;92(2):161-6. Epub 2007 Oct 26.)
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• Gender, socio-econominc status and metabolic syndrome in middle-aged and old adults.
  (Santos AC, et.al. BMC Public Health. 2008 Feb 18;8(1):62 [Epub ahead of print])
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• The metabolic syndrome and incident diabetes: Assessment of alternative definitions of the metabolic syndrome in an Iranian urban population.
  (Hadaegh F, et.al. Diabetes Res Clin Pract. 2008 Feb 16; [Epub ahead of print])
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Exercise

• Long-term cardiac rehabilitation and exercise training programs improve metabolic parameters in metabolic syndrome patients with and without coronary heart disease.
  (Gayda M, et.al. Nutr Metab Cardiovasc Dis. 2008 Feb;18(2):142-51. Epub 2006 Dec 4.)
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Genetics

• Variants in the CD36 gene associate with the metabolic syndrome and high density lipoprotein cholesterol.
  (Love-Gregory L, et.al. Hum Mol Genet. 2008 Feb 27; [Epub ahead of print])
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• The influence of polymorphism of -493G/T MTP gene promoter and metabolic syndrome on lipids, fatty acids and oxidative stress.
  (Zák A, et.al. J Nutr Biochem. 2008 Feb 13; [Epub ahead of print])
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• Association of the MC4R V103I polymorphism with the metabolic syndrome: The KORA Study.
  (Heid IM, et.al. Obesity (Silver Spring). 2008 Feb;16(2):369-76.)
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• Association of TCF7L2 polymorphism with diabetes mellitus, metabolic syndrome, and markers of beta cell function and insulin resistance in a population-based sample of Emirati subjects.
  (Saadi H, et.al. Diabetes Res Clin Pract. 2008 Feb 16; [Epub ahead of print])
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• Investigating the association between K198N coding polymorphism in EDN1 and hypertension, lipoprotein levels, the metabolic syndrome and cardiovascular disease.
  (Wiltshire S, et.al. Hum Genet. 2008 Feb 21; [Epub ahead of print])
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• The effects of chromosome 17 on features of the metabolic syndrome in the Lyon hypertensive rat (LH).
  (Gilibert S, et.al. Physiol Genomics. 2008 Feb 19; [Epub ahead of print])
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• Novel phenotypic markers and screening score for the metabolic syndrome in adult Asian Indians.
  (Misra A, et.al. Diabetes Res Clin Pract. 2008 Feb;79(2):e1-5. Epub 2007 Sep 18.)
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• Effect of weight loss on cytokine messenger RNA expression in peripheral blood mononuclear cells of obese subjects with the metabolic syndrome.
  (de Mello VD, et.al. Metabolism. 2008 Feb;57(2):192-9.)
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Hypertension

• Different BMI cardiovascular risk thresholds as markers of organ damage and metabolic syndrome in primary hypertension.
  (Litwin M, et.al. Pediatr Nephrol. 2008 Feb 6; [Epub ahead of print])
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• Effect of metabolic syndrome or type II diabetes mellitus on the occurrence of recurrent vascular events in hypertensive patients.
  (Vlek AL, et.al. J Hum Hypertens. 2008 Feb 14; [Epub ahead of print])
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Insulin Sensitivity / Insulin Resistance

• Endothelium-dependent vasodilation, insulin resistance and the metabolic syndrome in an elderly cohort: the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study.
  (Lind L.Atherosclerosis. 2008 Feb;196(2):795-802. Epub 2007 Feb 28.)
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Metabolic Syndrome in Women

• Small dense LDL particles and metabolic syndrome in a sample of middle-aged women. Findings from Progetto Atena.
  (Gentile M, et.al. Clin Chim Acta. 2008 Feb;388(1-2):179-83. Epub 2007 Nov 6.)
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• A randomized controlled trial of therapeutic lifestyle modification in rural women with metabolic syndrome: a pilot study.
  (Oh EG, et.al. Metabolism. 2008 Feb;57(2):255-61.)
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• Metabolic syndrome in females with polycystic ovary syndrome and International Diabetes Federation criteria.
  (Bhattacharya SM.J Obstet Gynaecol Res. 2008 Feb;34(1):62-6.)
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• The investigation and management of severe hyperandrogenism pre- and postmenopause: Non-tumor disease is strongly associated with metabolic syndrome and typically responds to insulin-sensitization with metformin.
  (Vaikkakara S, et.al. Gynecol Endocrinol. 2008 Feb;24(2):87-92.)
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• Prevalence of parameter indicators of obesity and its relationship with metabolic syndrome in urban Moroccan women.
  (Ayachi Mohammed E, et.al. Am J Hum Biol. 2008 Feb 21; [Epub ahead of print])
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• Mild gestational hyperglycaemia as a risk factor for metabolic syndrome in pregnancy and adverse perinatal outcomes.
  (Negrato CA, et.al. Diabetes Metab Res Rev. 2008 Feb 6; [Epub ahead of print])
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Non-Alcholic Fatty Liver Disease

• Metabolic syndrome and liver histology in paediatric non-alcoholic steatohepatitis.
  (Manco M, et.al. Int J Obes (Lond). 2008 Feb;32(2):381-7. Epub 2007 Dec 18.)
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Obesity

• Alterations in plasma and tissue lipids associated with obesity and metabolic syndrome.
  (Aguilera CM, et.al. Clin Sci (Lond). 2008 Feb;114(3):183-93. Review.)
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• Circulating adiponectin levels associate with inflammatory markers, insulin resistance and metabolic syndrome independent of obesity.
  (Hung J, et.al. Int J Obes (Lond). 2008 Feb 5; [Epub ahead of print])
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• The development of porcine models of obesity and the metabolic syndrome.
  (Spurlock ME, et.al. J Nutr. 2008 Feb;138(2):397-402.)
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• Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans.
  (Zhang X, et.al. Diabetes. 2008 Feb 5; [Epub ahead of print])
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• Vitamin D, PTH, and the metabolic syndrome in severely obese subjects.
  (Rueda S, et.al. Obes Surg. 2008 Feb;18(2):151-4. Epub 2008 Jan 4.)
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Pediatrics

• Path analysis of metabolic syndrome components in black versus white children, adolescents, and adults: the Bogalusa Heart Study.
  (Chen W, et.al. Ann Epidemiol. 2008 Feb;18(2):85-91.)
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• Defining the metabolic syndrome in children and adolescents: will the real definition please stand up?
  (Ford ES, et.al. J Pediatr. 2008 Feb;152(2):160-4. Epub 2007 Oct 31. Review.)
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• Carotid artery wall hypertrophy in children with metabolic syndrome.
  (Iannuzzi A, et.al. J Hum Hypertens. 2008 Feb;22(2):83-8. Epub 2007 Oct 11.)
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• Sensitivity, specificity, and predictive values of pediatric metabolic syndrome components in relation to adult metabolic syndrome: the Princeton LRC follow-up study.
  (Huang TT, et.al. J Pediatr. 2008 Feb;152(2):185-90. Epub 2007 Oct 22.)
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• Short- and long-term relationships of serum ghrelin with changes in body composition and the metabolic syndrome in prepubescent obese children following two different weight loss programs.
  (Kelishadi R, et.al. Clin Endocrinol (Oxf). 2008 Feb 11; [Epub ahead of print])
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• Children and adolescents with obesity and the metabolic syndrome have high circulating cortisol levels.
  (Sen Y, et.al. Neuro Endocrinol Lett. 2008 Feb 24;29(1):141-145 [Epub ahead of print])
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• Low-grade inflammation and the metabolic syndrome in children and adolescents.
  (Wärnberg J, et.al. Curr Opin Lipidol. 2008 Feb;19(1):11-5.)
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• Association between the metabolic syndrome and serum cortisol in overweight Latino youth.
  (Weigensberg MJ, et.al. J Clin Endocrinol Metab. 2008 Feb 5; [Epub ahead of print])
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• Metabolic syndrome traits in long-term survivors of pediatric sarcoma.
  (Hoffman KE, et.al. Pediatr Blood Cancer. 2008 Feb;50(2):341-6.)
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• Metabolic syndrome in childhood predicts adult metabolic syndrome and type 2 diabetes mellitus 25 to 30 years later.
  (Morrison JA, et.al. J Pediatr. 2008 Feb;152(2):201-6. Epub 2007 Nov 5.)
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• Metabolic syndrome and its association with diet and physical activity in US adolescents.
  (Pan Y, et.al. J Am Diet Assoc. 2008 Feb;108(2):276-86.)
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• Comparison of different definitions of pediatric metabolic syndrome: relation to abdominal adiposity, insulin resistance, adiponectin, and inflammatory biomarkers.
  (Lee S, et.al. J Pediatr. 2008 Feb;152(2):177-84. Epub 2007 Oct 22.)
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• Examining metabolic syndrome definitions in overweight Hispanic youth: a focus on insulin resistance.
  (Shaibi GQ, et.al. J Pediatr. 2008 Feb;152(2):171-6. Epub 2007 Oct 22.)
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• Childhood obesity predicts adult metabolic syndrome: the Fels Longitudinal Study.
  (Sun SS, et.al. J Pediatr. 2008 Feb;152(2):191-200. Epub 2007 Oct 31.)
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Psychiatric Disorders

• Concordance of standard and modified NCEP ATP III criteria for identification of metabolic syndrome in outpatients with schizophrenia treated with antipsychotics: A corollary from the CLAMORS study.
  (Rejas J, et.al. Schizophr Res. 2008 Feb;99(1-3):23-8. Epub 2007 Dec 11.)
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• Typical and atypical antipsychotics differentially affect long-term incidence rates of the metabolic syndrome in first-episode patients with schizophrenia: A retrospective chart review.
  (De Hert M, et.al. Schizophr Res. 2008 Feb 23; [Epub ahead of print])
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• The prevalence of metabolic syndrome in patients with bipolar disorder.
  (Garcia-Portilla MP, et.al. J Affect Disord. 2008 Feb;106(1-2):197-201. Epub 2007 Jul 12.)
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• Metabolic syndrome in first episode schizophrenia - A randomized double-blind controlled, short-term rospective study.
  (Saddichha S, et.al. Schizophr Res. 2008 Feb 8; [Epub ahead of print])
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• Modal subcomponents of metabolic syndrome in patients with bipolar disorder.
  (Cardenas J, et.al. J Affect Disord. 2008 Feb;106(1-2):91-7. Epub 2007 Jul 12.)
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Risk Factors

• Optimizing management of metabolic syndrome to reduce risk: focus on life-style.
  (Bianchi C, et.al. Intern Emerg Med. 2008 Feb 13; [Epub ahead of print])
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• Weight fluctuations and risk for metabolic syndrome in an adult cohort.
  (Vergnaud AC, et.al. Int J Obes (Lond). 2008 Feb;32(2):315-21. Epub 2007 Oct 30.)
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Sleep Disorders

• Obstructive sleep apnea and metabolic syndrome: alterations in glucose metabolism and inflammation.
  (Tasali E, et.al. Proc Am Thorac Soc. 2008 Feb;5(2):207-17.)
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