June 2007
Volume 2, issue 6


The Metabolic Syndrome Institute Literature Watch features the latest articles on the metabolic syndrome. Click on the links below to view the abstracts for each article.

Adipokines

  • The emerging role of adipokines as mediators of inflammation and immune responses.
    Lago F, Dieguez C, Gómez-Reino J, Gualillo O.
    Cytokine Growth Factor Rev. 2007 May 14; [Epub ahead of print]
    View Abstract
  • Adiponectin: Saving the starved and the overfed.
    Behre CJ.
    Med Hypotheses. 2007 May 15; [Epub ahead of print]
    View Abstract
  • Role of adiponectin and adipocyte fatty acid binding protein in the metabolic syndrome.
    Maeda K.
    Diabetes Res Clin Pract. 2007 May 2; [Epub ahead of print]
    View Abstract


Adipose Tissue Disorders

  • Omental 11{beta}-hydroxysteroid dehydrogenase 1 correlates with fat cell size independently of obesity.
    Michailidou Z, Jensen MD, Dumesic DA, Chapman KE, Seckl JR, Walker BR, Morton NM.
    Obesity (Silver Spring) . 2007 May;15(5):1155-1163.
    View Abstract

Cardiovascular Disease

  • Insulin resistance, the metabolic syndrome, and risk of incident cardiovascular disease: a population-based
    study.

    Jeppesen J, Hansen TW, Rasmussen S, Ibsen H, Torp-Pedersen C, Madsbad S.
    J Am Coll Cardiol . 2007 May 29;49(21):2112-9. Epub 2007 May 17.
    View Abstract
  • Cardiac structure and function and arterial circulation in hypertensive patients with and without metabolic syndrome.
    Ferrara LA, Guida L, Ferrara F, De Luca G, Staiano L, Celentano A, Mancini M.
    J Hum Hypertens. 2007 May 24; [Epub ahead of print]
    View Abstract
  • Impaired coronary function in Wistar Ottawa Karlsburg W rats-a new model of the metabolic syndrome.
    Buck BJ, Kerman IA, Burghardt PR, Koch LG, Britton SL, Akil H, Watson SJ.
    Pflugers Arch. 2007 May 1; [Epub ahead of print]
    View Abstract

Diabetes

  • Probable blind spot in the international diabetes Federation definition of metabolic syndrome.
    Chen HJ, Pan WH.
    Obesity (Silver Spring). 2007 May;15(5):1096-100.
    View Abstract

Diet, Nutrition and Metabolism

  • Effect of a single high-fat meal on endothelial function in patients with the metabolic syndrome: role of tumor necrosis factor-alpha.
    Esposito K, Ciotola M, Sasso FC, Cozzolino D, Saccomanno F, Assaloni R, Ceriello A, Giugliano D.
    Nutr Metab Cardiovasc Dis. 2007 May;17(4):274-9. Epub 2006 Jul 11.
    View Abstract
  • Dietary carbohydrate modification induces alterations in gene expression in abdominal subcutaneous adipose tissue in persons with the metabolic syndrome: the FUNGENUT Study.
    Kallio P, Kolehmainen M, Laaksonen DE, Kekäläinen J, Salopuro T, Sivenius K, Pulkkinen L, Mykkänen HM, Niskanen L, Uusitupa M, Poutanen KS.
    Am J Clin Nutr. 2007 May;85(5):1417-27.
    View Abstract
  • Metabolic syndrome: Effects of n-3 PUFAs on a model of dyslipidemia, insulin resistance and adiposity.
    Lombardo YB, Hein G, Chicco A.
    Lipids. 2007 May;42(5):427-37.
    View Abstract
  • Intake of dietary magnesium and the prevalence of the metabolic syndrome among U.S. adults.
    Ford ES, Li C, McGuire LC, Mokdad AH, Liu S.
    Obesity (Silver Spring). 2007 May;15(5):1139-46.
    View Abstract
  • Dietary soya intake alters plasma antioxidant status and lipid peroxidation in postmenopausal women with the metabolic syndrome.
    Azadbakht L, Kimiagar M, Mehrabi Y, Esmaillzadeh A, Hu FB, Willett WC.
    Br J Nutr. 2007 May 17;:1-7 [Epub ahead of print] No abstract available.
    View Abstract

Drug Therapy

  • Treating the metabolic syndrome.
    Bianchi C, Penno G, Romero F, Del Prato S, Miccoli R.
    Expert Rev Cardiovasc Ther. 2007 May;5(3):491-506. Review.
    View Abstract
  • Effects of growth hormone and pioglitazone in viscerally obese adults with impaired glucose tolerance:
    a factorial clinical trial.

    Attallah H, Friedlander AL, Nino-Murcia M, Hoffman AR.
    PLoS Clin Trials. 2007 May 4;2(5):e21.
    View Abstract

Epidemiology

  • Impact of metabolic syndrome on the development of cardiovascular disease in a general Japanese population. The Hisayama Study.
    Ninomiya T, Kubo M, Doi Y, Yonemoto K, Tanizaki Y, Rahman M, Arima H, Tsuryuya K, Iida M, Kiyohara Y.
    Stroke. 2007 May 24; [Epub ahead of print]
    View Abstract
  • Metabolic syndrome and incident cardiovascular morbidity and mortality in a mediterranean hypertensive population.
    Andreadis EA, Tsourous GI, Tzavara CK, Georgiopoulos DX, Katsanou PM, Marakomichelakis GE, Diamantopoulos EJ.
    Am J Hypertens. 2007 May;20(5):558-64.
    View Abstract
  • Defining the metabolic syndrome construct: Multi-ethnic study of atherosclerosis cross-sectional analysis.
    Vaidya D, Szklo M, Liu K, Schreiner PJ, Bertoni AG, Ouyang P.
    Diabetes Care. 2007 May 7; [Epub ahead of print]
    View Abstract
  • Contribution of the metabolic syndrome to sudden death risk in asymptomatic men: the Paris Prospective Study I.
    Empana JP, Duciemetiere P, Balkau B, Jouven X.
    Eur Heart J. 2007 May;28(9):1149-54.
    View Abstract
  • Different waist circumferences, different metabolic risks in koreans.
    Joo NS, Kim BT, Park SB, Kong MH, Lee TY, Kim KM.
    J Am Board Fam Med. 2007 May-Jun;20(3):258-65.
    View Abstract

Exercise & Physical Activity

  • Clinical aspects of physical exercise for diabetes/metabolic syndrome.
    Sato Y, Nagasaki M, Kubota M, Uno T, Nakai N.
    Diabetes Res Clin Pract. 2007 May 9; [Epub ahead of print]
    View Abstract
  • Exercise and diet induced weight loss improves measures of oxidative stress and insulin sensitivity in adults with characteristics of the metabolic syndrome.
    Rector RS, Warner SO, Liu Y, Hinton PS, Sun G, Cox RH, Stump CS, Laughlin MH, Dellsperger KC, Thomas TR.
    Am J Physiol Endocrinol Metab. 2007 May 1; [Epub ahead of print]
    View Abstract

Genetics

  • Association of the estrogen receptor alpha gene with the metabolic syndrome and its component traits in
    African American families: The IRAS Family Study.

    Gallagher CJ, Langefeld CD, Gordon CJ, Campbell JK, Mychaleckyj JC, Bryer-Ash M, Rich SS, Bowden DW, Sale MM.
    Diabetes. 2007 May 18; [Epub ahead of print]
    View Abstract
  • L-FABP T94A is associated with fasting triglycerides and LDL-cholesterol in women.
    Fisher E, Weikert C, Klapper M, Lindner I, Möhlig M, Spranger J, Boeing H, Schrezenmeir J, Döring F.
    Mol Genet Metab. 2007 May 5; [Epub ahead of print]
    View Abstract
  • TAK-536, a new AT(1) receptor blocker, improves glucose intolerance and adipocyte differentiation.
    Iwai M, Chen R, Imura Y, Horiuchi M.
    Am J Hypertens. 2007 May;20(5):579-86.
    View Abstract
  • Upregulation of GAD65 mRNA in the medulla of the rat model of metabolic syndrome.
    Buck BJ, Kerman IA, Burghardt PR, Koch LG, Britton SL, Akil H, Watson SJ.
    Neurosci Lett. 2007 May 29;419(2):178-83. Epub 2007 Apr 25.
    View Abstract

Insulin Sensitivity / Insulin Resistance

  • Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance.
    Odegaard JI, Ricardo-Gonzalez RR, Goforth MH, Morel CR, Subramanian V, Mukundan L, Red Eagle A, Vats D, Brombacher F, Ferrante AW, Chawla A.
    Nature. 2007 May 21; [Epub ahead of print]
    View Abstract
  • Is there any relation between insulin resistance and cognitive function in the elderly?
    Isik AT, Cankurtaran M, Bozoglu E, Comert B, Doruk H, Mas MR.
    Int Psychogeriatr. 2007 May 14;:1-12 [Epub ahead of print]
    View Abstract

Non-Alcoholic Fatty Liver Disease

  • Abnormal lipid and glucose metabolism in obesity: implications for nonalcoholic fatty liver disease.
    Parekh S, Anania FA.
    Gastroenterology. 2007 May;132(6):2191-207.
    View Abstract
  • What are the risk factors and settings for non-alcoholic fatty liver disease in Asia-Pacific?
    Fan JG, Saibara T, Chitturi S, Kim BI, Sung JJ, Chutaputti A; the Asia–Pacific Working Party for NAFLD.
    J Gastroenterol Hepatol. 2007 May 13; [Epub ahead of print]
    View Abstract
  • A growing burden: the pathogenesis, investigation and management of non-alcoholic fatty liver disease.
    Riley P, O'donohue J, Crook M.
    J Clin Pathol. 2007 May 4; [Epub ahead of print]
    View Abstract
  • Evaluation of risk profiles by subcutaneous adipose tissue topography in obese juveniles.
    Moeller R, Horejsi R, Pilz S, Lang N, Sargsyan K, Dimitrova R, Tafeit E, Giuliani A, Almer G, Mangge H.
    Obesity (Silver Spring). 2007 May;15(5):1319-24.
    View Abstract
  • The genetics of nonalcoholic fatty liver disease.
    Osterreicher CH, Brenner DA.
    Ann Hepatol. 2007 Apr-Jun;6(2):83-8.
    View Abstract

Obesity

  • Effects of diet-induced moderate weight reduction on intrahepatic and intramyocellular triglycerides and glucose metabolism in obese subjects.
    Sato F, Tamura Y, Watada H, Kumashiro N, Igarashi Y, Uchino H, Maehara T, Kyogoku S, Sunayama S, Sato H, Hirose T, Tanaka Y, Kawamori R.
    J Clin Endocrinol Metab. 2007 May 22; [Epub ahead of print]
    View Abstract

PCOS / Menopause / Metabolic Syndrome in Women

  • Prenatal androgen excess negatively impacts body fat distribution in a nonhuman primate model of polycystic ovary syndrome.
    Bruns CM, Baum ST, Colman RJ, Dumesic DA, Eisner JR, Jensen MD, Whigham LD, Abbott DH.
    Int J Obes (Lond). 2007 May 1; [Epub ahead of print]
    View Abstract
  • Insulin sensitivity after metformin suspension in normal-weight women with polycystic ovary syndrome.
    Palomba S, Falbo A, Russo T, Manguso F, Tolino A, Zullo F, De Feo P, Orio F.
    J Clin Endocrinol Metab. 2007 May 22; [Epub ahead of print]
    View Abstract
  • A new rat model exhibiting both ovarian and metabolic characteristics of polycystic ovary syndrome.
    Mannerås L, Cajander S, Holmäng A, Seleskovic Z, Lystig T, Lönn M, Stener-Victorin E.
    Endocrinology. 2007 May 10; [Epub ahead of print]
    View Abstract
  • C-reactive protein before and after weight loss in overweight women with and without polycystic ovary
    syndrome.

    Moran LJ, Noakes M, Clifton PM, Wittert GA, Belobrajdic DP, Norman RJ.
    J Clin Endocrinol Metab. 2007 May 15;
    View Abstract

Pediatrics

  • Relationship between the change in overweight status from childhood to adolescence and metabolic syndrome phenotypes: a 9-year retrospective study.
    Kim KR, Kim MK, Shin YJ, Choi BY.
    Eur J Clin Nutr. 2007 May 16; [Epub ahead of print]
    View Abstract
  • Serum concentrations of uric acid and the metabolic syndrome among US children and adolescents.
    Ford ES, Li C, Cook S, Choi HK.
    Circulation. 2007 May 15;115(19):2526-32.
    View Abstract
  • Insulin resistance: link to the components of the metabolic syndrome and biomarkers of endothelial dysfunction in youth.
    Lee S, Gungor N, Bacha F, Arslanian S.
    Diabetes Care. 2007 May 7; [Epub ahead of print]
    View Abstract
  • Childhood overweight, obesity, and the metabolic syndrome in developing countries.
    Kelishadi R.
    Epidemiol Rev. 2007 May 3; [Epub ahead of print]
    View Abstract

Risk Factors

  • Prevalence of the metabolic syndrome in individuals with hyperuricemia.
    Choi HK, Ford ES.
    Am J Med. 2007 May;120(5):442-7.
    View Abstract
  • Psychosocial risk factors and the metabolic syndrome in elderly persons: findings from the health, aging and body composition study.
    Vogelzangs N, Beekman AT, Kritchevsky SB, Newman AB, Pahor M, Yaffe K, Rubin SM, Harris TB, Satterfield S, Simonsick EM, Penninx BW.
    J Gerontol A Biol Sci Med Sci . 2007 May;62(5):563-9.
    View Abstract
  • Metabolic syndrome increases the risk of ischemic stroke in women.
    Takahashi K, Bokura H, Kobayashi S, Iijima K, Nagai A, Yamaguchi S.
    Intern Med. 2007;46(10):643-648. Epub 2007 May 24.
    View Abstract
  • Insulin resistance, the metabolic syndrome, and risk of incident cardiovascular disease a population-based study.
    Jeppesen J, Hansen TW, Rasmussen S, Ibsen H, Torp-Pedersen C, Madsbad S.
    J Am Coll Cardiol. 2007 May 29;49(21):2112-2119. Epub 2007 May 17.
    View Abstract
  • Clusters of metabolic risk factors predict cardiovascular events in hypertension with target-organ damage: the LIFE study.
    de Simone G, Olsen MH, Wachtell K, Hille DA, Dahlöf B, Ibsen H, Kjeldsen SE, Lyle PA, Devereux RB.
    J Hum Hypertens. 2007 May 3; [Epub ahead of print]
    View Abstract
  • Patients with metabolic syndrome exhibit higher platelet activity than those with conventional risk factors for vascular disease.
    Serebruany VL, Malinin A, Ong S, Atar D.
    J Thromb Thrombolysis. 2007 May 26; [Epub ahead of print]
    View Abstract
  • Metabolic syndrome: Psychosocial, neuroendocrine and classical risk factors in type 2 diabetes.
    Abraham NG, Brunner EJ, Eriksson JW, Robertson RP.
    Ann N Y Acad Sci. 2007 May 18; [Epub ahead of print]
    View Abstract
  • Ten-year change in serum uric acid and its relation to changes in other metabolic risk factors in young black and white adults: the CARDIA study.
    Abraham NG, Brunner EJ, Eriksson JW, Robertson RP.
    Eur J Epidemiol. 2007 May 5
    View Abstract

Sleep Disorders

  • The prevalence of syndrome Z (the interaction of obstructive sleep apnoea with the metabolic syndrome) in a teaching hospital in Singapore.
    Venkateswaran S, Shankar P.
    Postgrad Med J. 2007 May;83(979):329-31.
    View Abstract
  • Obstructive sleep apnea syndrome is associated with some components of metabolic syndrome.
    Kono M, Tatsumi K, Saibara T, Nakamura A, Tanabe N, Takiguchi Y, Kuriyama T.
    Chest. 2007 May;131(5):1387-92.
    View Abstract

 

Coordinated by Dr. Scott Grundy, President of the IAS