• Adiponectin, insulin resistance and clinical expression of the metabolic syndrome in patients with Type 2 diabetes.
  Mojiminiyi OA, Abdella NA, Al Arouj M, Ben Nakhi A.
  Int J Obes (Lond). 2007 Feb;31(2):213-20. Epub 2006 Jun 6.
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• Leptin reversal of the metabolic phenotype: evidence for the role of developmental plasticity in the development of the metabolic syndrome.
  Gluckman PD, Beedle AS, Hanson MA, Vickers MH.
  Horm Res. 2007;67 Suppl 1:115-20. Epub 2007 Feb 15.
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• Adiponectin and cardiovascular disease: response to therapeutic interventions.
  Han SH, Quon MJ, Kim JA, Koh KK.
  J Am Coll Cardiol. 2007 Feb 6;49(5):531-8. Epub 2007 Jan 19.
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Adipose Tissue Disorders

• Metabolic syndrome pathophysiology: the role of adipose tissue.
  Laclaustra M, Corella D, Ordovas JM.
  Nutr Metab Cardiovasc Dis. 2007 Feb;17(2):125-39. Epub 2007 Jan 30. Review.
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• Characterisation of 11beta-hydroxysteroid dehydrogenase 1 in human orbital adipose tissue: a comparison with subcutaneous and omental fat.
  Bujalska IJ, Durrani OM, Abbott J, Onyimba CU, Khosla P, Moosavi AH, Reuser TT, Stewart PM, Tomlinson JW, Walker EA, Rauz S.
  J Endocrinol. 2007 Feb;192(2):279-88.
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• T-cell accumulation and regulated on activation, normal T cell expressed and secreted upregulation in adipose tissue in obesity.
  Wu H, Ghosh S, Perrard XD, Feng L, Garcia GE, Perrard JL, Sweeney JF, Peterson LE, Chan L, Smith CW, Ballantyne CM.
  Circulation. 2007 Feb 27;115(8):1029-38. Epub 2007 Feb 12.
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Cardiovascular Disease

• Cardiologist's role in improving glucose control and global cardiovascular risk in patients with type 2 diabetes mellitus.
  Gotto AM Jr.
  Am J Cardiol. 2007 Feb 19;99(4A):3B-5B. Epub 2006 Dec 20.
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• Gene by sex interaction in the etiology of coronary heart disease and the preceding metabolic syndrome.
  McCarthy JJ.
  Nutr Metab Cardiovasc Dis. 2007 Feb;17(2):153-61. Epub 2006 Mar 31. Review.
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• The metabolic syndrome predicts cardiovascular mortality: a 13-year follow-up study in elderly non-diabetic Finns.
  Wang J, Ruotsalainen S, Moilanen L, Lepisto P, Laakso M, Kuusisto J.
  Eur Heart J. 2007 Feb 15; [Epub ahead of print]
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Diabetes

• Weight management for type 2 diabetes mellitus: global cardiovascular risk reduction.
  Lee M, Aronne LJ.
  Am J Cardiol. 2007 Feb 19;99(4A):68B-79B. Epub 2006 Dec 27.
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• Inflammation in diabetes mellitus: role of peroxisome proliferator-activated receptor-alpha and peroxisome proliferator-activated receptor-gamma agonists.
  Libby P, Plutzky J.
  Am J Cardiol. 2007 Feb 19;99(4A):27B-40B. Epub 2006 Dec 22.
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• The prediction of major outcomes of Type 1 diabetes: A 12 year prospective evaluation of three separate definitions of the Metabolic Syndrome, and their components and estimated glucose disposal rate: The Pittsburgh Epidemiology of Diabetes Complications Study Experience.
  Pambianco G, Costacou T, Orchard TJ.
  Diabetes Care. 2007 Feb 15; [Epub ahead of print]
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• Relation of the "hypertriglyceridemic waist" phenotype to earlier manifestations of coronary artery disease in patients with glucose intolerance and type 2 diabetes mellitus.
  St-Pierre J, Lemieux I, Perron P, Brisson D, Santure M, Vohl MC, Despres JP, Gaudet D.
  Am J Cardiol. 2007 Feb 1;99(3):369-73. Epub 2006 Dec 8.
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Diet, Nutrition and Metabolism

• Combined diet and exercise intervention reverses the metabolic syndrome in middle-aged males: results from the Oslo Diet and Exercise Study.
  Anderssen SA, Carroll S, Urdal P, Holme I.
  Scand J Med Sci Sports. 2007 Feb 28; [Epub ahead of print]
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• Prenatal exposure to a low protein diet programmes disordered regulation of lipid metabolism in the ageing rat.
  Erhuma AM, Salter AM, Sculley DV, Langley-Evans SC, Bennett A.
  Am J Physiol Endocrinol Metab. 2007 Feb 13; [Epub ahead of print]
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Drug Therapy

• Drug Insight: mechanisms of action and therapeutic applications for agonists of peroxisome proliferator-activated receptors.
  Gervois P, Fruchart JC, Staels B. Nat Clin Pract Endocrinol Metab. 2007 Feb;3(2):145-56. Review.
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• The frequency of aspirin resistance and its risk factors in patients with metabolic syndrome.
  Kahraman G, Sahin T, Kilic T, Baytugan NZ, Agacdiken A, Ural E, Ural D, Komsuoglu B.
  Int J Cardiol. 2007 Feb 14;115(3):391-6. Epub 2007 Jan 9.
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• Coronary heart disease in patients with diabetes: part I: recent advances in prevention and noninvasive management.
  Berry C, Tardif JC, Bourassa MG.
  J Am Coll Cardiol. 2007 Feb 13;49(6):631-42. Epub 2007 Jan 26. Review.
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• Acute effects of atypical antipsychotics on whole-body insulin resistance in rats: implications for adverse metabolic effects.
  Houseknecht KL, Robertson AS, Zavadoski W, Gibbs EM, Johnson DE, Rollema H.
  Neuropsychopharmacology. 2007 Feb;32(2):289-97. Epub 2006 Oct 11.
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Epidemiology

• Prevalence of the metabolic syndrome in patients with gout: the Third National Health and Nutrition Examination Survey.
  Choi HK, Ford ES, Li C, Curhan GArthritis Rheum. 2007 Feb 15;57(1):109-15.
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• Harmonizing the definition of the metabolic syndrome: comparison of the criteria of the Adult Treatment Panel III and the International Diabetes Federation in United States American and European populations.
  Assmann G, Guerra R, Fox G, Cullen P, Schulte H, Willett D, Grundy SM.
  Am J Cardiol. 2007 Feb 15;99(4):541-8. Epub 2007 Jan 2.
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• Prevalence, agreement and classification of various metabolic syndrome criteria among ethnic Chinese: A report on the hospital-based health diagnosis of the adult population.
  Chien KL, Lee BC, Hsu HC, Lin HJ, Chen MF, Lee YT.
  Atherosclerosis. 2007 Feb 7; [Epub ahead of print]
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• The metabolic syndrome and chronic kidney disease in a Southeast Asian cohort.
  Kitiyakara C, Yamwong S, Cheepudomwit S, Domrongkitchaiporn S, Unkurapinun N, Pakpeankitvatana V, Sritara P.
  Kidney Int. 2007 Feb 7; [Epub ahead of print]
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• Endothelium-dependent vasodilation, insulin resistance and the metabolic syndrome in an elderly cohort The Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study.
  Lind L.
  Atherosclerosis. 2007 Feb 27; [Epub ahead of print]
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• Cardiovascular risk factors in the urban Mexican population: The FRIMEX study.
  Meaney E, Lara-Esqueda A, Ceballos-Reyes GM, Asbun J, Vela A, Martinez-Marroquin Y, Lopez V, Meaney A, de la Cabada-Tamez E, Velazquez-Monroy O, Tapia-Conyer R.
  Public Health. 2007 Feb 8; [Epub ahead of print]
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• A cross-sectional study of socioeconomic status and the metabolic syndrome in Korean adults.
  Park MJ, Yun KE, Lee GE, Cho HJ, Park HS.
  Ann Epidemiol. 2007 Feb 12; [Epub ahead of print]
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• The ABCA1 R230C variant affects HDL-cholesterol levels and body mass index in the Mexican population: association with obesity and obesity-related comorbidities.
  Villarreal-Molina MT, Aguilar-Salinas CA, Rodriguez-Cruz M, Riano D, Villalobos-Comparan M, Coral-Vazquez R, Menjivar M, Yescas-Gomez P, Konisberg-Fainstein M, Romero-Hidalgo S, Tusie-Luna MT, Canizales-Quinteros S.
  Diabetes. 2007 Feb 7; [Epub ahead of print]
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Exercise & Physical Activity

• 3-week hiking holidays at moderate altitude do not impair cardiac function in individuals with metabolic syndrome.
  Mair J, Hammerer-Lercher A, Mittermayr M, Klingler A, Humpeler E, Pachinger O, Schobersberger W.
  Int J Cardiol. 2007 Feb 20; [Epub ahead of print]
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Genetics

• Central leptin gene therapy corrects skeletal abnormalities in leptin-deficient ob/ob mice.
  Iwaniec UT, Boghossian S, Lapke PD, Turner RT, Kalra SP.
  Peptides. 2007 Feb 12; [Epub ahead of print]
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• Restoration of coronary collateral growth in the Zucker obese rat: : Impact of VEGF and ecSOD.
  Hattan N, Chilian WM, Park F, Rocic P.
  Basic Res Cardiol. 2007 Feb 27; [Epub ahead of print]
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• Peroxisome proliferator-activated receptor-{delta} upregulates 14-3-3{varepsilon} in human endothelial cells via CCAAT/enhancer binding protein-{beta}
  Brunelli L, Cieslik KA, Alcorn JL, Vatta M, Baldini A.
  Circ Res. 2007 Feb 15; [Epub ahead of print]
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• Metabolic syndrome and ADRB3 gene polymorphism in severely obese patients from South Italy.
  Bracale R, Pasanisi F, Labruna G, Finelli C, Nardelli C, Buono P, Salvatori G, Sacchetti L, Contaldo F, Oriani G.
  Eur J Clin Nutr. 2007 Feb 14; [Epub ahead of print]
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• FABP2 Ala54Thr polymorphism and diabetes in Chilean elders.
  Albala C, Villarroel A, Santos JL, Angel B, Lera L, Liberman C, Sanchez H, Perez-Bravo F.
  Diabetes Res Clin Pract. 2007 Feb 9; [Epub ahead of print]
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• Expression of ectonucleotide pyrophosphate phosphodiesterase and peroxisome proliferator activated receptor gamma in morbidly obese patients.
  Brody F, Hill S, Celenski S, Kar R, Kluk B, Pinzone J, Fu S.
  Surg Endosc. 2007 Feb 8; [Epub ahead of print]
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• Insulin-resistant heart exhibits a mitochondrial biogenic response driven by the peroxisome proliferator-activated receptor-alpha/PGC-1alpha gene regulatory pathway.
  Duncan JG, Fong JL, Medeiros DM, Finck BN, Kelly DP.
  Circulation. 2007 Feb 20;115(7):909-17. Epub 2007 Jan 29.
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• Analysis of PGC-1alpha variants Gly482Ser and Thr612Met concerning their PPARgamma2-coactivation function.
  Nitz I, Ewert A, Klapper M, Doring F.
  Biochem Biophys Res Commun. 2007 Feb 9;353(2):481-6. Epub 2006 Dec 14.
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• Genetics of the metabolic syndrome.
  Teran-Garcia M, Bouchard C.
  Appl Physiol Nutr Metab. 2007 Feb;32(1):89-114.
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• The association of PC-1 (ENPP1) K121Q polymorphism with metabolic syndrome in patients with coronary heart disease.
  Tasic I, Milojkovic M, Sunder-Plassmann R, Lazarevic G, Tasic NM, Stefanovic V.
  Clin Chim Acta. 2007 Feb;377(1-2):237-42. Epub 2006 Oct 11.
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Hypertension

• Relationship of metabolic syndrome with pulse pressure in patients with essential hypertension.
  Mule G, Nardi E, Cottone S, Cusimano P, Incalcaterra F, Palermo A, Giandalia ME, Mezzatesta G, Andronico G, Cerasola G.
  Am J Hypertens. 2007 Feb;20(2):197-203.
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• The role of renin-angiotensin system inhibition in the treatment of hypertension in metabolic syndrome: are all the angiotensin receptor blockers equal?
  Karagiannis A, Mikhailidis DP, Athyros VG, Kakafika AI, Tziomalos K, Liberopoulos EN, Florentin M, Elisaf M.
  Expert Opin Ther Targets. 2007 Feb;11(2):191-205.
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• Role of magnesium in hypertension.
  Sontia B, Touyz RM.
  Arch Biochem Biophys. 2007 Feb 1;458(1):33-9. Epub 2006 May 24.
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• Hyperuricemia and incidence of hypertension among men without metabolic syndrome.
  Krishnan E, Kwoh CK, Schumacher HR, Kuller L.
  Hypertension. 2007 Feb;49(2):298-303. Epub 2006 Dec 26.
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Insulin Sensitivity / Insulin Resistance

• Insulin-resistant heart exhibits a mitochondrial biogenic response driven by the peroxisome proliferator-activated receptor-alpha/PGC-1alpha gene regulatory pathway.
  Duncan JG, Fong JL, Medeiros DM, Finck BN, Kelly DP.
  Circulation. 2007 Feb 20;115(7):909-17. Epub 2007 Jan 29.
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• Review: Insulin and endothelin: an interplay contributing to hypertension development?
  Sarafidis PA, Bakris GL.
  J Clin Endocrinol Metab. 2007 Feb;92(2):379-85. Epub 2006 Nov 21.
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• The operative risk factors in the metabolic syndrome: is it lipids and high BP or are there direct vascular effects of insulin resistance and obesity.
  Martens FM, Visseren FL.
  Curr Diab Rep. 2007 Feb;7(1):74-81.
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Lipoproteins

• Brain glucose metabolism controls the hepatic secretion of triglyceride-rich lipoproteins.
  Lam TK, Gutierrez-Juarez R, Pocai A, Bhanot S, Tso P, Schwartz GJ, Rossetti L.
  Nat Med. 2007 Mar;13(2):171-180. Epub 2007 Feb 4.
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• Serum apolipoprotein B predicts dyslipidemia, metabolic syndrome and, in women, hypertension and diabetes, independent of markers of central obesity and inflammation.
  Onat A, Can G, Hergenc G, Yazici M, Karabulut A, Albayrak S.
  Int J Obes (Lond). 2007 Feb 13; [Epub ahead of print]
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• Impaired postprandial apolipoprotein-B48 metabolism in the obese, insulin-resistant JCR:LA-cp rat: increased atherogenicity for the metabolic syndrome.
  Vine DF, Takechi R, Russell JC, Proctor SD.
  Atherosclerosis. 2007 Feb;190(2):282-90. Epub 2006 Apr 19.
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• Haplotypes in the lipoprotein lipase gene influence high-density lipoprotein cholesterol response to statin therapy and progression of atherosclerosis in coronary artery bypass grafts.
  Goodarzi MO, Taylor KD, Scheuner MT, Antoine HJ, Guo X, Shah PK, Rotter JI.
  Pharmacogenomics J. 2007 Feb;7(1):66-73. Epub 2006 Jun 6.
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Non-Alcoholic Fatty Liver Disease

• Hypertension and fatty liver: guilty by association?
  Brookes MJ, Cooper BT.
  J Hum Hypertens. 2007 Feb 1; [Epub ahead of print]
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• Nonalcoholic fatty liver disease in severely obese subjects.
  Gholam PM, Flancbaum L, Machan JT, Charney DA, Kotler DP.
  Am J Gastroenterol. 2007 Feb;102(2):399-408.
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• Prevalence of nonalcoholic fatty liver disease and its association with cardiovascular disease among type 2 diabetic patients.
  Targher G, Bertolini L, Padovani R, Rodella S, Tessari R, Zenari L, Day C, Arcaro G.
  Diabetes Care. 2007 Feb 2; [Epub ahead of print]
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• Genetics of alcoholic liver disease and nonalcoholic fatty liver disease.
  Wilfred de Alwis NM, Day CP.
  Semin Liver Dis. 2007 Feb;27(1):44-54.
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Obesity

• Abdominal obesity: role in the pathophysiology of metabolic disease and cardiovascular risk.
  Bergman RN, Kim SP, Hsu IR, Catalano KJ, Chiu JD, Kabir M, Richey JM, Ader M.
  Am J Med. 2007 Feb;120(2 Suppl 1):S3-8.
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• Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2.
  Le Bacquer O, Petroulakis E, Paglialunga S, Poulin F, Richard D, Cianflone K, Sonenberg N.
  J Clin Invest. 2007 Feb;117(2):387-96.
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• Review: Peroxisome proliferator-activated receptor gamma and adipose tissue--understanding obesity-related changes in regulation of lipid and glucose metabolism.
  Sharma AM, Staels B.
  J Clin Endocrinol Metab. 2007 Feb;92(2):386-95. Epub 2006 Dec 5.
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PCOS / Menopause / Metabolic Syndrome in Women

• Women with mitochondrial haplogroup N9a are protected against metabolic syndrome.
  Tanaka M, Fuku N, Nishigaki Y, Matsuo H, Segawa T, Watanabe S, Kato K, Yoko K, Ito M, Nozawa Y, Yamada Y.
  Diabetes. 2007 Feb;56(2):518-21.
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• Rosiglitazone treatment increases plasma levels of adiponectin and decreases levels of resistin in overweight women with PCOS: a randomized placebo-controlled study.
  Majuri A, Santaniemi M, Rautio K, Kunnari A, Vartiainen J, Ruokonen A, Kesaniemi YA, Tapanainen JS, Ukkola O, Morin-Papunen L.
  Eur J Endocrinol. 2007 Feb;156(2):263-9.
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• C-reactive protein and metabolic syndrome in women with previous gestational diabetes.
  Di Cianni G, Lencioni C, Volpe L, Ghio A, Cuccuru I, Pellegrini G, Benzi L, Miccoli R, Del Prato S.
  Diabetes Metab Res Rev. 2007 Feb;23(2):135-40.
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• Serum apolipoprotein B predicts dyslipidemia, metabolic syndrome and, in women, hypertension and diabetes, independent of markers of central obesity and inflammation.
  Onat A, Can G, Hergenc G, Yazici M, Karabulut A, Albayrak S.
  Int J Obes (Lond). 2007 Feb 13; [Epub ahead of print]
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Pediatrics

• Utility of the modified ATP III defined metabolic syndrome and severe obesity as predictors of insulin resistance in overweight children and adolescents: a cross-sectional study.
  Dhuper S, Cohen HW, Daniel J, Gumidyala P, Agarwalla V, St Victor R, Dhuper S.
  Cardiovasc Diabetol. 2007 Feb 14;6:4.
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• Adiponectin independently predicts metabolic syndrome in overweight latino youth.
  Shaibi GQ, Cruz ML, Weigensberg MJ, Toledo-Corral CM, Lane CJ, Kelly LA, Davis JN, Koebnick C, Ventura EE, Roberts CK, Goran MI.
  J Clin Endocrinol Metab. 2007 Feb 20; [Epub ahead of print]
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• Systolic blood pressure in childhood predicts hypertension and metabolic syndrome later in life.
  Sun SS, Grave GD, Siervogel RM, Pickoff AA, Arslanian SS, Daniels SR.
  Pediatrics. 2007 Feb;119(2):237-46.
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• Association between adult and childhood socioeconomic status and prevalence of the metabolic syndrome in African Americans: the Pitt County Study.
  Lucove JC, Kaufman JS, James SA.
  Am J Public Health. 2007 Feb;97(2):234-6. Epub 2006 Dec 28.
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• Development of age-specific adolescent metabolic syndrome criteria that are linked to the Adult Treatment Panel III and International Diabetes Federation criteria.
  Jolliffe CJ, Janssen I.
  J Am Coll Cardiol. 2007 Feb 27;49(8):891-8. Epub 2007 Feb 9.
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• The prevalence of the metabolic syndrome in young adults. The Cardiovascular Risk in Young Finns Study.
  Mattsson N, Ronnemaa T, Juonala M, Viikari JS, Raitakari OT.
  J Intern Med. 2007 Feb;261(2):159-69.
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Prothrombotic State

• Obesity and thrombosis.
  Darvall KA, Sam RC, Silverman SH, Bradbury AW, Adam DJ.
  Eur J Vasc Endovasc Surg. 2007 Feb;33(2):223-33. Epub 2006 Dec 20.
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Risk Factors

• Metabolic syndrome: a multiplex cardiovascular risk factor.
  Grundy SM.
  J Clin Endocrinol Metab. 2007 Feb;92(2):399-404.
  View Abstract
• Levels of homocysteine are increased in metabolic syndrome patients but are not associated with an increased cardiovascular risk, in contrast to patients without the metabolic syndrome.
  Hajer GR, van der Graaf Y, Olijhoek JK, Verhaar MC, Visseren FL; SMART Study Group.
  Heart. 2007 Feb;93(2):216-20. Epub 2006 Sep 4.
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• Is the metabolic syndrome an independent risk factor for erectile dysfunction?
  Heidler S, Temml C, Broessner C, Mock K, Rauchenwald M, Madersbacher S, Ponholzer A.
  J Urol. 2007 Feb;177(2):651-4.
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• Accuracy of anthropometric indicators of obesity to predict cardiovascular risk.
  Schneider HJ, Glaesmer H, Klotsche J, Bohler S, Lehnert H, Zeiher AM, Marz W, Pittrow D, Stalla GK, Wittchen HU; DETECT Study Group.
  J Clin Endocrinol Metab. 2007 Feb;92(2):589-94. Epub 2006 Nov 14.
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• High prevalence of the metabolic syndrome in patients with systemic lupus erythematosus: association with disease characteristics and cardiovascular risk factors.
  Chung CP, Avalos I, Oeser A, Gebretsadik T, Shintani A, Raggi P, Michael Stein C.
  Ann Rheum Dis. 2007 Feb;66(2):208-14. Epub 2006 Aug 10.
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Sleep Disorders

• Jennings JR, Muldoon MF, Hall M, Buysse DJ, Manuck SB.
  Self-reported sleep quality is associated with the metabolic syndrome.
  Sleep. 2007 Feb 1;30(2):219-23.
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