Baseline leptin concentrations negatively correlated with weight loss degree in lifestyle interventions
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Leptin is involved in fuel partitioning, and circulating leptin levels parallel white adipose tissue mass and reflect nutritional status. This study was based on the hypothesis that leptin levels are negatively correlated with degree of weight loss in obese children participating in lifestyle interventions. To this end, 248 obese children attending the “Obeldicks” lifestyle intervention were studied. Among these, 212 children reduced their overweight, 9 children dropped out, and 27 children did not reduce overweight during the lifestyle intervention. Reduction of standard deviation score-body mass index, waist circumference, and percentage body fat were significantly and negatively associated with baseline leptin levels. Multiple regression analyses revealed that baseline leptin concentrations were significantly associated with body mass index, pubertal stage, gender, waist circumference, and insulin, but not with any other cardiovascular risk factors. These results support the hypothesis of leptin resistance in children obesity.
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