Interaction of sleep-disordered breathing and metabolic abnormalities in overweight and obese children and adolescents

This study was aimed to examine whether 1) sleep-disordered breathing (SDB) is a risk factor of metabolic syndrome in overweight children and adolescents; 2) the severity of SDB is independently associated with glucose intolerance, insulin resistance, and/or dyslipidaemia. To this end, a total of 104 consecutive obese or overweight children underwent polysomnography, fasting blood glucose measure, and oral glucose tolerance testing for calculation of the area under the curve (AUC). Mean SaO2 and SaO2nadir were independent, significant predictors of the presence of metabolic syndrome. After controlling for adiposity and sex, puberty, or both, multiple regression analysis showed significant associations between SaO2nadir and high-density lipoprotein cholesterol level, mean SaO2 and both AUC glucose and triglyceride levels, and between the percentage of total sleep time with SaO2≥95% and cholesterol level.

Abstract

Keywords:
Adipose tissue – HDL-cholesterol – Metabolic syndrome – Obesity – OGTT – Overweight – Triglycerides