Prevalence of the metabolic syndrome shown to increase with increasing levels of serum uric acid
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The metabolic syndrome is a frequent comorbidity of hyperuricaemia, and renal clearance of urate is inversely related to insulin resistance. Based on data of 8669 participants consisting of a nationally representative sample of US adults from the Third National Health and Nutrition Examination Survey (NHANES 1988-1994), the prevalence of the metabolic syndrome at different uric acid levels was assessed by using both the revised and the original ATP III metabolic syndrome criteria. With the revised criteria, the prevalences of the metabolic syndrome were 18.9% for uric acid levels less than 6 mg/dL, 36,0% for uric acid levels from 6 to 6.9 mg/dL, 40.8% for uric acid levels from 7 to 7.9 mg/dL, 59.7% for uric acid levels from 8 to 8.9 mg/dL, 62.0% for uric acid levels from 9 to 9.9 mg/dL, and 70,7% for uric acid levels of 10 mg/dL or greater. With the original criteria, the prevalences of the metabolic syndrome were slightly lower. The increasing trends persisted after stratifying patients by sex, age, alcohol intake, body mass index, hypertension and diabetes.
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