Predictors of the incident metabolic syndrome in adults: the Insulin Resistance Atherosclerosis Study.
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Predictors of the incident metabolic syndrome in adults: the Insulin Resistance Atherosclerosis Study. 139 of the 714 white, black, and Hispanic participants in the Insulin Resistance Atherosclerosis Study (IRAS) who were free of the metabolic syndrome at baseline developed the metabolic syndrome in the subsequent 5 years. After adjustment for age, sex, study site, ethnicity, and impaired glucose tolerance, the best predictors of incident metabolic syndrome were waist circumference (>89 cm in women, >102 cm in men; odds ratio [OR] 1.7 [1.3-2.0] per 11 cm), followed by HDL cholesterol (0.6 [0.4-0.7] per 15 mg/dl) and proinsulin (1.7 [1.4-2.0] per 3.3 pmol/l). Waist circumference was the optimal predictor.
Authors: Palaniappan L, Carnethon MR, Wang Y, Hanley AJ, Fortmann SP, Haffner SM, Wagenknecht L; Insulin Resistance Atherosclerosis Study
PMID/ref: Diabetes Care 2004;27(3):788-93.
