Mechanism of triglyceride lowering in mice expressing human apolipoprotein A5
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Overexpression of human APOA5 in mice results in dramatically decreased plasma triglyceride levels. This study shows that triglyceride turnover is faster in human APOA5 transgenic mice, and that this strongly correlated with increased LPL activity. These data indicated that apoAV induces a decrease in VLDL size by activating lipolysis and increasing VLDL clearance.
Author: Fruchart-Najib J, Baugé E, Niculescu LS, Pham T, Thomas B, Rommens C, Majd Z, Brewer B, Pennacchio LA, Fruchart JC.
PMID/ref: Biochem Biophys Res Commun 319:397-404, 2004
