A review article on the plasminogen activator inhibitor 1 - 06/2005

Historical analysis of PAI-1 from its discovery to its potential role in cell motility and disease.

In this review, the authors discuss the discovery, origin, properties and regulation of the plasminogen activator inhibitor 1 (PAI-1), one of the primary regulators of the fibrinolytic system, and speculate about its potential role in vascular disease, fibrosis, obesity and the metabolic syndrome, and cancer.

Themes : Metabolic Syndrome and Pathophysiology

Author(s) :
Dellas C, Loskutoff DJ.

Reference :
Thromb Haemost 2005;93:631-40.

Pubmed reference :
PMID: 15841306