Endothelial function impaired in patients with hypertension, metabolic syndrome - 04/2005

Abnormal capillary permeability and endothelial dysfunction in hypertension with comorbid Metabolic Syndrome.- 2005

The transcapillary escape rate of albumin was higher in 24 non-diabetic, uncomplicated hypertensive men with metabolic syndrome (hypertension with at least two additional traits) than in 12 age-matched lean normal hypertensive patients with normal lipid and glucose profile and 9 normotensive subjects. Forearm vasodilation to intra-arterial acetylcholine, an index of nitric oxide-mediated vasomotor dysfunction, was selectively attenuated in metabolic syndrome patients. The coexistence of altered systemic capillary permeability, which may promote early atherosclerosis development, with blunted endothelial-mediated vasodilation indicates a pervasive abnormality of endothelial function.

Themes : Metabolic Syndrome and Hypertension

Author(s) :
Dell'Omo G, Penno G, Pucci L, Mariani M, Del Prato S, Pedrinelli R.

Reference :
Atherosclerosis. 2004 Feb;172(2):383-9

Pubmed reference :
PMID: 15019550