To evaluate the efficiency of advanced serum apolipoprotein profile for predicting stable coronary artery disease (CAD) in secondary prevention, 138 men and 126 women aged 40 – 70 years were classified as CAD cases or controls according to the results of coronary artery angiography. The severity of CAD was scored on the basis of the number and the extent of coronary artery lesions; serum apolipoproteins(apo) were measured by immunoturbidometric and electrophoresis methods. Multiple logistic regression analysis adjusted for major risk factors showed that the apoB/apoAI ratio, apoB, and lipoprotein(a) were independent risk factors for CAD and the results suggested them to be superior to any of the cholesterol ratios. As a conclusion, the authors propose using the apoB/apoAI ratio as the best marker for CAD in clinical practice.